Synthesis of small molecule histone deacetylase 6 degraders, compounds formed thereby, and pharmaceutical compositions containing them
US11059815B2 · kind B2 · utility
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14Claims
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Key dates
| Filing date | Feb 25, 2020 |
| Grant date | Jul 13, 2021 |
| Priority date | — |
| Expiry date | Feb 25, 2040 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D401/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Histone deacetylase (“HDAC”)-selective inhibitors covalently bonded to a linker covalently bonded to an E3 ubiquitin ligase ligand, and salts thereof; pharmaceutical compositions containing them; methods of using the composition to inhibit neoplastic cell growth in mammals, including humans.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.