Patent · US Active

Spirobicyclic analogues

US11059850B2 · kind B2 · utility

6Cited by

2References

21Claims

0Family size

Assignee

Janssen Pharmaceuticals, Inc. · BE

Inventors

Jonas Verhoeven · Brussels, BE
Guido Alfons F. Verniest · Beerse, BE
Johannes Wilhelmus John F. Thuring · Ekeren, BE
Tongfei Wu · Leuven, BE
Vineet Pande · Vosselaar, BE
Lieven Meerpoel · Beerse, BE
Dirk Brehmer · Glückstadt, DE
Weimei Sun · North Wales, US
Scott E. Denmark · Urbana, US

Key dates

Filing date	Dec 6, 2018
Grant date	Jul 13, 2021
Priority date	—
Expiry date	Dec 6, 2038

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07H19/14
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The present invention relates to novel spirobicyclic analogues of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.