Antimicrobial peptides and methods of making and using same
US11059855B2 · kind B2 · utility
0Cited by
4References
8Claims
0Family size
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Key dates
| Filing date | Mar 12, 2018 |
| Grant date | Jul 13, 2021 |
| Priority date | — |
| Expiry date | Mar 12, 2038 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides a new methodology combining MD simulations and database-guided high-throughput screening to rationally design pore forming membrane-active peptides. The present inventive methodology is able to allow tuning of a range of structural and functional properties such as pore size and selectively targeting membranes with specific lipid compositions. The present inventive methods will ultimately allow de novo design of membrane-active peptides for a wide range of biomedical applications, including for example, antimicrobial agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.