Methods and compositions for producing double allele knock outs
US11060083B2 · kind B2 · utility
1Cited by
8References
19Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 19, 2017 |
| Grant date | Jul 13, 2021 |
| Priority date | — |
| Expiry date | Dec 13, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y302/01018
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention provides a method and compositions utilizing the CRISPR system to disrupt a target gene in eukaryotic cells to produce double allele knock outs. The method finds use in producing afucosylated antibodies with enhanced ADCC activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.