Nucleic acid sequencing systems
US11060138B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Sep 9, 2020 |
| Grant date | Jul 13, 2021 |
| Priority date | — |
| Expiry date | Sep 9, 2040 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2201/0612
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Methods and systems for sequencing a nucleic acid molecule are described that comprise imaging a first surface and an axially-displaced second surface using a compensation-free optical system, the system comprising an objective lens and at least one image sensor, wherein said optical system has a numerical aperture (NA) of less than 0.6 and a field-of-view (FOV) of greater than 1.0 mm2; and) processing the images of the first surface and the axially-displaced second surface to correct for optical aberration such that the images of the first surface and the axially-displaced second surface have substantially the same optical resolution.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.