Patent · US Active

Compositions of fosaprepitant and methods of preparation

US11065265B2 · kind B2 · utility

1Cited by

2References

19Claims

0Family size

Assignee

Spes Pharmaceuticals Inc. · US

Inventors

Jianwei Yu · Plainsboro, US
Yulu Wang · Longbeilingcun, CN

Key dates

Filing date	Jan 11, 2019
Grant date	Jul 20, 2021
Priority date	—
Expiry date	Jan 11, 2039

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K47/40
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present application and its embodiments teach stable compositions of fosaprepitant or a pharmaceutically acceptable salt thereof with such compositions lacking polysorbate 80 and containing dual functional excipients of hydrolysis inhibition and solubility enhancement. Further described are methods of preparation of such compositions. Among other advantages of contemplated compositions, fosaprepitant hydrolysis degradation is kept low and the compositions maintain physically and chemically stable for prolonged period.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.