Rapafucin derivative compounds and methods of use thereof

US11066416B2 · kind B2 · utility

Assignees

• THE JOHNS HOPKINS UNIVERSITY · US
• Rapafusyn Pharmaceuticals, Inc. · US

Inventors

• Jun Liu · Clarksville, US
• Sam Hong · Baltimore, US
• Brett Ullman · San Diego, US
• Joseph Edward Semple · Wilmington, US
• Kana Yamamoto · Toledo, US
• Puneet Kumar · Manesar, IN
• Magesh Sadagopan · Baltimore, US
• Jennifer C. Schmitt · Baltimore, US

Key dates

• Filing date: Oct 1, 2019
• Grant date: Jul 20, 2021
• Expiry date: Oct 1, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/6561
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present disclosure provides macrocyclic compounds inspired by the immunophilin ligand family of natural products FK506 and rapamycin. The generation of a Rapafucin library of macrocyles that contain FK506 and rapamycin binding domains should have great potential as new leads for developing drugs to be used for treating diseases.