Method for inducing human cholangiocyte differentiation
US11066649B2 · kind B2 · utility
0Cited by
1References
15Claims
0Family size
Assignees
Inventors
Key dates
| Filing date | Mar 19, 2015 |
| Grant date | Jul 20, 2021 |
| Priority date | — |
| Expiry date | Sep 6, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2533/54
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to a method for inducing human cholangiocyte differentiation of progenitor cells called hepatoblasts. More specifically, the invention relates to a method for differentiating hepatoblasts to cholangiocytes by culturing said hepatoblasts with a particular medium having interleukin-6 (IL-6) activity. The differentiation method can specifically induce cholangiocyte differentiation from hepatoblasts, and the human cholangiocytes differentiated according to the invention may be useful for drug discovery for treatment of cholangiopathies and bioengineered livers.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.