Closed-ended linear duplex DNA for non-viral gene transfer
US11066679B2 · kind B2 · utility
7Cited by
4References
16Claims
0Family size
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Key dates
| Filing date | Mar 3, 2017 |
| Grant date | Jul 20, 2021 |
| Priority date | — |
| Expiry date | Sep 8, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2750/14151
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Aspects of the disclosure relate to a nucleic acid comprising a heterologous nucleic acid insert flanked by interrupted self-complementary sequences, wherein one self-complementary sequence is interrupted by a cross-arm sequence forming two opposing, lengthwise-symmetric stem-loops, and wherein the other of the self-complementary sequences is interrupted by a truncated cross-arm sequence. Methods of delivering the nucleic acid to a cell are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.