Allosteric modulators of the mu opioid receptor
US11071731B2 · kind B2 · utility
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13Claims
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Assignee
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Key dates
| Filing date | Feb 26, 2020 |
| Grant date | Jul 27, 2021 |
| Priority date | — |
| Expiry date | Feb 26, 2040 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D401/14
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed herein are compounds, of the class of amine-bearing heterocycles, which act as positive allosteric modulators and silent allosteric modulators of the mu opioid receptor. These compounds are useful for the treatment of pain, drug addiction, and other CNS derived maladies that are controlled directly or indirectly by activation of the mu opioid receptor. Methods for making and using the allosteric modulators disclosed herein are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.