1,2,4-triazole and preparation method therefor
US11072589B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Oct 11, 2020 |
| Grant date | Jul 27, 2021 |
| Priority date | — |
| Expiry date | Oct 11, 2040 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01J27/122
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
A method for preparing 1,2,4-triazole includes using a fluoroborate aryl diazonium salt, a diazoester derivative and an organic nitrile as reaction substrates, a transition metal salt as a catalyst, and an inorganic base as an additive in a cyclization reaction. The method has the following characteristics: the reaction is economical; the substrate is universal; the post-functionalization is easy; the reaction conditions are mild; the reaction can be performed in air; the catalyst amount used is less; and the post-treatment is simple. Meanwhile, the raw materials, such as the reactants and the catalyst used, are inexpensive and easily available; the reaction composition is reasonable; no ligand is needed; there are less reaction steps; and only one step of reaction is required to obtain a high yield, meeting the requirements and directions of contemporary green chemistry and medicinal chemistry, being suitable for screening highly active 1,2,4-triazole drugs.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.