μ-opioid receptor agonist and preparation method therefor and use thereof in field of medicine

US11072601B2 · kind B2 · utility

Assignees

• SHANGHAI SYNERGY PHARMACEUTICAL SCIENCES CO., LTD · CN
• ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD. · CN

Inventors

• Xin Xu · Dongying, CN
• Zhen Zhang · Shanghai, CN
• Yunfei Li · Fremont, US
• Liming Zhang · Hangzhou City, CN
• Fengying Guo · Shanghai, CN
• Qingyun Jiang · Shanghai, CN
• Dongsheng Li · Shanghai, CN
• Linli Zhang · Houston, US
• Jinqian Song · Shanghai, CN
• Lei Liu · Thousand Oaks, US
• Qiang Liu · Saskatoon, CA
• Jing Su · Scotch Plains, US
• Yijin Wang · Dongguan, CN
• Jian Ge · Hubei, CN

Key dates

• Filing date: Sep 17, 2018
• Grant date: Jul 27, 2021
• Expiry date: Sep 17, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D495/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are a class of μ-opioid receptor agonists and a preparation method therefor and the use thereof in the field of medicine, belonging to the field of medicinal chemistry. The μ-opioid receptor agonists significantly increase the selectivity for a G protein signaling pathway, and not only can exhibit excellent pharmacodynamic effects, but also significantly improve safety.