Cyclic peptides targeting alpha-4-beta-7 integrin
US11072616B2 · kind B2 · utility
2Cited by
8References
40Claims
0Family size
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Key dates
| Filing date | Nov 14, 2016 |
| Grant date | Jul 27, 2021 |
| Priority date | — |
| Expiry date | Feb 12, 2037 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
There is described herein antagonists of α4β7 integrin, and more particularly to cyclic peptide antagonists. Accordingly, there is described herein a compound of formula (I) wherein R1, R2, R3, R4, R5, R6, R7 and R8 are various substituents; stereocentres 1*, 2* and 3* are each independently selected from R and S; n is 1, 2, 3, or 4 and where n is 2-4, Z is an amino terminus of an amino acid; —C═O— adjacent L is the carboxy terminus of an amino acid; and L along with Z and —C═O— is a peptide.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.