HPV-specific binding molecules

US11072660B2 · kind B2 · utility

Assignee

• Juno Therapeutics, Inc. · US

Inventors

• James Sissons · Seattle, US
• Cameron S. Brandt · Seattle, US
• Alexandra Croft · Seattle, US
• Allen Ebens · Redwood City, US
• Haley Peper · Seattle, US
• Dean Y. Toy · Seattle, US

Key dates

• Filing date: Oct 3, 2017
• Grant date: Jul 27, 2021
• Expiry date: Oct 3, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided are binding molecules, such as TCRs or antigen binding fragments thereof and antibodies and antigen-binding fragments thereof, such as those that recognize or bind human papilloma virus (HPV) 16, including HPV 16 E6 and HPV 16 E7. Also provided are engineered cells containing such binding molecules, compositions containing the binding molecules or engineered cells, and methods of treatment, such as administration of the binding molecules, engineered cells, or compositions.