Abuse-deterrent pharmaceutical composition

US11077196B2 · kind B2 · utility

Assignee

• G.L. PHARMA GMBH · AT

Inventors

• Georg GUEBITZ · Graz, AT
• Katrin Greimel · Graz, AT
• Martin Brandauer · Wien, AT
• Daniela Huber · Hollabrunn, AT
• Klaus Bleymaier · Wien, AT
• Wolfgang Kroutil · Graz, AT
• Doris Lechner · Graz, AT
• Christof Wachter · Lannach, AT
• Harald Wagner · Graz, AT
• Heimo Winkler · Graz, AT

Key dates

• Filing date: Feb 28, 2017
• Grant date: Aug 3, 2021
• Expiry date: Aug 18, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N9/13
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed is an abuse-deterrent pharmaceutical composition comprising a drug with an enzyme-reactive functional group, wherein the drug has an abuse potential, and an enzyme capable of reacting with the enzyme-reactive functional group (a drug-processing enzyme), wherein the drug with the enzyme-reactive functional group is contained in the pharmaceutical composition in a storage stable, enzyme-reactive state and under conditions wherein no enzymatic activity acts on the drug.