5-membered and bicyclic heterocyclic amides as inhibitors of rock
US11078197B2 · kind B2 · utility
2Cited by
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16Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 11, 2018 |
| Grant date | Aug 3, 2021 |
| Priority date | — |
| Expiry date | Jul 14, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D519/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically-acceptable salts thereof wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.