Patent · US Active

Preparation and use of molecular site targeted and activated kinase inhibitor

US11078232B2 · kind B2 · utility

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6Claims

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Assignee

Yafei Shanghai Biology Medicine Science & Technology Co. Ltd. · CN

Inventors

Yuan Liu · Suzhou, CN
Cheng Liu · Great Neck, US
Haiyang Wang · 流花街道, CN

Key dates

Filing date	Jan 16, 2018
Grant date	Aug 3, 2021
Priority date	—
Expiry date	Jan 16, 2038

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K45/06
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Disclosed are molecularly targeted and activated kinase inhibitors and use thereof. Specifically, a compound represented by the following formula A or a pharmaceutically acceptable salt thereof, wherein X is a polar and a non-polar uncharged amino acid such as alanine, proline or threonine; A is alanine; N is asparagine; PABC is —NH-phenyl-CH2-O—; and Z is a drug molecule; wherein the lactobionic acid residue, XAN and PABC are linked to each other by an amide bond; PABC is bonded to Z by an ester group, i.e., —OC(O)—.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.