High titer recombinant AAV vector production in adherent and suspension cells
US11078464B2 · kind B2 · utility
1Cited by
27References
14Claims
0Family size
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Key dates
| Filing date | Aug 28, 2014 |
| Grant date | Aug 3, 2021 |
| Priority date | — |
| Expiry date | Aug 28, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2750/14152
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention is directed to an in vitro method of producing a recombinant AAV virion in a mammalian host cell that comprises a functional adenoviral E1A gene and rAAV virions made by the method. Host cells are transfected with varying ratios of plasmids comprising the E1A gene and virions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.