Lysine decarboxylases having modifications at titratable amino acids
US11078473B2 · kind B2 · utility
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14Claims
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Key dates
| Filing date | Dec 30, 2016 |
| Grant date | Aug 3, 2021 |
| Priority date | — |
| Expiry date | Dec 30, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y401/01018
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention provides CadA polypeptides with mutations that increase activity in alkaline pH compared to the wild-type lysine decarboxylase. The invention also provides methods of generating such mutant polypeptides, microorganisms genetically modified to overexpress the mutant polypeptides, and methods of generating such microorganisms.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.