Patent · US Active

Aqueous composition

US11078511B2 · kind B2 · utility

3Cited by

1References

1Claims

0Family size

Assignee

Roche Diagnostics Operations, Inc. · US

Inventors

Harald Sobek · Penzberg, DE
Michael Greif · Penzberg, DE
Marco Thomann · Beuerberg, DE
Sebastian Malik · Antdorf, DE

Key dates

Filing date	Jun 21, 2017
Grant date	Aug 3, 2021
Priority date	—
Expiry date	Jun 21, 2037

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2317/41
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The present disclosure is directed to the properties of certain glycosyltransferase variants having N-terminal truncation deletions or internal deletions. Any of the mutants disclosed in here exhibit alpha-2,6-sialyltransferase enzymatic activity in the presence of CMP-activated sialic acid as co-substrate, and in the presence of a suitable acceptor site. A fundamental finding documented in the present disclosure is that these enzymes are not only capable of catalyzing transfer of a sialidyl moiety but they are also capable of catalyzing hydrolytic cleavage of terminally bound sialic acid from a glycan.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.