Patent · US Active

Synthetic nucleic acid spike-ins

US11078532B2 · kind B2 · utility

2Cited by

9References

40Claims

0Family size

Assignee

KARIUS, INC. · US

Inventors

Fred Christians · Los Altos Hills, US
Igor D. Vilfan · East Palo Alto, US
Michael Kertesz · Menlo Park, US
Timothy A. Blauwkamp · Palo Alto, US
Shivkumar Venkatasubrahmanyam · San Jose, US
Michael Rosen · Palo Alto, US
Rene Sit · Sunnyvale, US

Key dates

Filing date	Apr 16, 2018
Grant date	Aug 3, 2021
Priority date	—
Expiry date	Jul 23, 2038

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Q2600/166
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

This disclosure provides methods for determining relative abundance of one or more non-host species in a sample from a host. Also provided are methods involving addition of known concentrations of synthetic nucleic acids to a sample and performing sequencing assays to identify non-host species such as pathogens. Also provided are methods of tracking samples, tracking reagents, and tracking diversity loss in sequencing assays.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.