Method and apparatus for providing a pharmacokinetic drug dosing regimen

US11081211B2 · kind B2 · utility

Assignee

• Baxalta Incorporated · CH

Inventors

• Kameswara Rao Kuchimanchi · Lexington, US
• Alexandra Loew-Baselli · Wien, AT
• Gerald Spotts · Lexington, US
• Myungshin Oh · Los Angeles, US
• Michael Don Hale · Raleigh, US
• Martin Wolfsegger · Wien, AT

Key dates

• Filing date: Oct 14, 2020
• Grant date: Aug 3, 2021
• Expiry date: Oct 14, 2040

Classification

• Technology area (CPC G): Physics
• CPC primary: G16C20/70
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Systems and methods providing a clotting factor VIII dosing regimen are disclosed. The systems and methods include determining an estimated pharmacokinetic profile of a patient using a Bayesian model of pharmacokinetic profiles of sampled patients. The systems and methods can determine a first dosing regimen for a first dosing interval including (i) a first dosage and (ii) a first therapeutic plasma protein level in the patient varying over time based at least upon the estimated pharmacokinetic profile. The systems and methods can determine a second dosing regimen for a second dosing interval including (i) a second dosage and (ii) a second therapeutic plasma protein level in the patient varying over time. The estimated pharmacokinetic profile can be adjusted based on previous patient treatments. Further, a user can select which days a dosage is to be applied such that the protein level does not fall below a target trough.