Pharmacological restoration of epithelial or endothelial barrier integrity by agents blocking EPAC/RAP1 signaling
US11083708B2 · kind B2 · utility
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Key dates
| Filing date | Aug 23, 2019 |
| Grant date | Aug 10, 2021 |
| Priority date | — |
| Expiry date | Aug 23, 2039 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/0053
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods and pharmaceutical compositions for treating diseases characterized by compromised epithelial or endothelial barrier integrity are provided. The pharmaceutical compositions include an effective amount a Epac/Rap1 signaling inhibitor. The methods include administering to a patient suffering from a disease characterized by compromised epithelial or endothelial barrier integrity a therapeutically effective amount of a Epac/Rap1 signaling inhibitor, such as ESI-09, SecinH3, Slit, or AG1024.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.