Patent · US Active

Use of negative modulators of GABA receptors containing alpha5 subunits as fast acting antidepressants

US11083732B2 · kind B2 · utility

0Cited by

0References

11Claims

0Family size

Assignee

UNIVERSITY OF MARYLAND, BALTIMORE · US

Inventors

Scott Thompson · Denver, US
Mark D. Kvarta · Ellicott City, US
Adam Van Dyke · Baltimore, US

Key dates

Filing date	Mar 31, 2015
Grant date	Aug 10, 2021
Priority date	—
Expiry date	Nov 26, 2035

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P25/24
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Embodiments of the disclosure include methods and compositions related to treatment of one or more medical conditions with one or more negative modulators of GABAA receptors. In specific embodiments, depression and/or suicidability is treated or ameliorated or prevented with one or more negative modulators of GABAA receptors, such as a partial inverse agonist of a GABAA receptor comprising an alpha5 subunit.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.