Method for producing 1-methylpyrrolidin-3-ol
US11084787B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Feb 9, 2017 |
| Grant date | Aug 10, 2021 |
| Priority date | — |
| Expiry date | Sep 25, 2038 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01J23/44
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
The invention relates to a method of producing compound (I) by (A) reacting compound (II) formaldehyde and hydrogen in the presence of a metal catalyst, in a solvent, wherein the amount of the formaldehyde to be used is exceeding 1 mol and not exceeding 5 mol per 1 mol of compound (II), to obtain a mixture containing the formaldehyde and compound (I), and (B) mixing the obtained mixture containing the formaldehyde and compound (I) with hydrogen and a secondary amine selected from the group consisting of diethylamine, dipropylamine, diisopropylamine, butylethylamine, pyrrolidine, piperidine and morpholine, in the presence of a metal catalyst, in a solvent, and then removing the metal catalyst, followed by obtaining the compound (I) by distillation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.