Benzopiperazine compositions as BET bromodomain inhibitors

US11084831B1 · kind B1 · utility

Assignee

• FORMA Therapeutics, Inc. · US

Inventors

• Kenneth W. Bair · Chapel Hill, US
• Torsten Herbertz · Stow, US
• Goss S. Kauffman · Ledyard, US
• Katherine J. Kayser-Bricker · Branford, US
• George P. Luke · Clinton, US
• Matthew W. Martin · Arlington, US
• David S. Millan · Watertown, US
• Shawn Schiller · Haverhill, US
• Adam Charles Talbot · Guilford, US
• Mark J. Tebbe · Hamburg, DE

Key dates

• Filing date: May 12, 2020
• Grant date: Aug 10, 2021
• Expiry date: May 12, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D495/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to inhibitors of bromo and extra terminal (BET) bromodomains that are useful for the treatment of cancer, inflammatory diseases, diabetes, and obesity, having Formula (I): wherein X, Y, Z, R1, R2, R4 and R7 are defined herein.