Anti-TREM2 antibodies and methods of use thereof

US11084875B2 · kind B2 · utility

Assignee

• Alector LLC

Inventors

• Kate Monroe · Berkeley, US
• Tina SCHWABE · San Francisco, US
• Francesca Avogadri-Connors · Lasów Chojnowskich, US
• Ilaria TASSI · San Francisco, US
• Helen LAM · Union City, US
• Arnon Rosenthal · Woodside, US

Key dates

• Filing date: Apr 11, 2019
• Grant date: Aug 10, 2021
• Expiry date: Sep 7, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/92
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention is generally directed to methods and compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind a TREM2 protein, e.g., a mammalian TREM2 and/or human TREM2. The methods provided herein find use in preventing, reducing risk, or treating an individual having dementia, frontotemporal dementia, Alzheimer's disease, Nasu-Hakola disease, or multiple sclerosis.