Synthesis of novel disulfide linker based nucleotides as reversible terminators for DNA sequencing by synthesis

US11085076B2 · kind B2 · utility

Assignee

• The Trustees of Columbia University in the City of New York · US

Inventors

• Jingyue Ju · Englewood Cliffs, US
• Xiaoxu Li · New York, US
• Xin Chen · Lexington, US
• Zengmin Li · Great Neck, US
• Shiv Kumar · Montgomery, US
• Shundi Shi · Queens, US
• Cheng Guo · Schenectady, US
• Jianyi Ren · New York, US
• Min-Kang Hsieh · Radford, US
• Minchen Chien · Tenafly, US
• Chuanjuan Tao · Fort Lee, US
• Ece Erturk · New York, US
• Sergey Kalachikov · New York, US
• James J. Russo · New York, US

Key dates

• Filing date: Sep 28, 2016
• Grant date: Aug 10, 2021
• Expiry date: Dec 16, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H19/20
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing of a nucleic acid.