Identification and use of circulating nucleic acids

US11085084B2 · kind B2 · utility

Assignee

• The Board of Trustees of the Leland Stanford Junior University · US

Inventors

• Maximilian Diehn · San Carlos, US
• Arash Ash Alizadeh · San Mateo, US
• Aaron M. Newman · San Mateo, US
• Daniel Klass · Palo Alto, US

Key dates

• Filing date: Sep 11, 2015
• Grant date: Aug 10, 2021
• Expiry date: May 27, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C40B20/04
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Disclosed herein are polynucleotide adaptors and methods of use thereof for identifying and analyzing nucleic acids, including cell-free nucleic acids from a patient sample. Also disclosed herein are methods of using the adaptors to detect, diagnose, or determine prognosis of cancers.