Method and composition for treating gastro-esophageal disorders
US11090329B2 · kind B2 · utility
Inventors
Key dates
| Filing date | May 1, 2017 |
| Grant date | Aug 17, 2021 |
| Priority date | — |
| Expiry date | Jun 28, 2038 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG06Q10/06375
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An orally administered composition that includes least one alkaline agent with a pH of at least 9.0 to 12.0, mixed in an aqueous vehicle with relatively high surface tension, high viscosity and lateral adhesion properties. When mixed, a low water soluble emulsion is formed that evenly coats and partially adheres to the lower section of the esophagus and the LES and forms a relatively long acting, protective barrier and partially neutralizes gastric acid. Mixed in the composition is at least one catechin 0.01 to 0.05% by weight. The alkaline agent is potassium hydroxide and the aqueous vehicle is made of hydroxypropyl methyl cellulose, polyethylene glycol or ethylene glycol and additional thickener agents capable of withstanding high pH environments, such as xanthan gum, croscarmellose sodium, and microcrystalline cellulose. Additional organoleptic agents, such as gum Arabic and polyethylene glycol, flavorings, such as sodium chloride, acesulfame potassium, sodium saccharine, and mint, and stabilizers such as colloidal silica made be added.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.