Method for preparing urate transporter 1 inhibitor

US11091448B2 · kind B2 · utility

Assignee

• Tianjin Institute of Pharmaceutical Research Co., Ltd. · CN

Inventors

• Guilong Zhao · Tianjin, CN
• Changying Liu · Tianjin, CN
• Yuqiang Liu · Beijing, CN
• Huihui Chen · Tianjin, CN
• Yuquan Li · Tianjin, CN
• Haizhi Zhang · Tianjin, CN
• Yafei Xie · Tianjin, CN
• Jingwei Wu · 达尔罕壕村, CN
• Wei Liu · Hangzhou City, CN
• Weiren Xu · Tianjin, CN
• Meixiang Zou · Tianjin, CN
• Lida Tang · Tianjin, CN

Key dates

• Filing date: Jun 26, 2017
• Grant date: Aug 17, 2021
• Expiry date: Jul 7, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D249/08
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Provided is a method for preparing a URAT1 inhibitor, 2-((5-bromo-4-((4-bromonaphthalen-1-yl)methyl)-4H-1,2,4-triazol-3-yl)thio) acetic acid represented by the following formula ZXS-BR, the reaction equation of which being shown as follows. Compared with the prior art, the preparation method provided by the present application is of low cost, ease of handling, ease of quality control, and applicable to industrialization.