Preparation of racemic nicotine by reaction of ethyl nicotinate with N-vinylpyrrolidone in the presence of an alcoholate base and subsequent process steps
US11091458B2 · kind B2 · utility
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18Claims
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Key dates
| Filing date | Dec 18, 2018 |
| Grant date | Aug 17, 2021 |
| Priority date | — |
| Expiry date | Dec 18, 2038 |
Classification
- Technology area (CPC —)General
Abstract
The present invention relates to a method of preparing racemic nicotine comprising: (i) reacting ethyl nicotinate and N-vinylpyrrolidone in the presence of an alcoholate base to 3-nicotinoyl-1-vinylpyrrolidin-2-one; (ii) reacting the 3-nicotinoyl-1-vinylpyrrolidin-2-one with an acid to myosmine; (iii) reducing the myosmine to nornicotine using a reducing agent; and (iv) methylating the nornicotine to obtain the racemic nicotine.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.