1-cyano-pyrrolidine derivatives as inhibitors of USP30
US11091488B2 · kind B2 · utility
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18Claims
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Key dates
| Filing date | Nov 29, 2016 |
| Grant date | Aug 17, 2021 |
| Priority date | — |
| Expiry date | Jan 25, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D513/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylatin-enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase 30 or Ubiquitin Specific Peptidase 30 (USP30). The invention further relates to the use of DUB inhibitors in the treatment of conditions involving mitochondrial dysfunction and cancer. Compounds of the invention include compounds having the formula (I) (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, m, L and X are as defined herein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.