Solid forms and combination compositions comprising a beta-lactamase inhibitor and uses thereof

US11091505B2 · kind B2 · utility

Assignee

• VENATORX PHARMACEUTICALS, INC. · US

Inventors

• Christopher J. Burns · Vivonne Bay, AU
• Daniel C. Pevear · Downingtown, US
• Luigi XERRI · Wayne, US
• Timothy Henkel · Berwyn, US
• Daniel McGarry · King of Prussia, US
• Lawrence ROSEN · Malvern, US
• Gerald S. Brenner · Norristown, US
• Jean-Baptiste Arlin · Amsterdam, NL
• Ana Fernandez Casares · Amsterdam, NL

Key dates

• Filing date: Mar 5, 2018
• Grant date: Aug 17, 2021
• Expiry date: Mar 5, 2038

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/546
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Described herein are crystalline forms of (R)-3-(2-(trans-4-(2-aminoethylamino)cyclohexyl)acetamido)-2-hydroxy-3,4-dihydro-2H-benzo[e][1,2]oxaborinine-8-carboxylic acid. In some embodiments, the crystalline forms are formulated for treating a subject in need thereof with a bacterial infection.