Carbohydrate ligands that bind to antibodies against glycoepitopes of glycosphingolipids
US11091591B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Sep 14, 2016 |
| Grant date | Aug 17, 2021 |
| Priority date | — |
| Expiry date | Feb 24, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H15/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to carbohydrate ligands and moieties, respectively, mimicking glycoepitopes comprised by glycosphingolipids of the nervous system, particularly glycoepitopes comprised by glycosphingolipids of the cerebroside, the globoside-, the ganglioside- and the sulfoglucuronyl paragloboside type, which are bound by anti-glycan antibodies associated with neurological diseases. The invention further relates to the use of these carbohydrate ligands/moieties, in diagnosis as well as for the treatment of neurological diseases associated with anti-glycan antibodies. In particular, the invention relates to compounds of formula (I) and (II) and to therapeutically acceptable polymers comprising a multitude of these compounds, including polymers with loading of one compound of formula (I) or (II) or combinations of several compounds of formula (I), and/or (II). The compounds of formula (I) are defined as: wherein RI1 is Z or wherein RI2 is H, SO3H, or wherein RI3 is H or wherein RI4 is H or wherein RI5 and RI6 are independently H or wherein RI7 is H or and compounds of formula (II) are defined as: wherein RII1 is Z or wherein RII2 is Z or wherein Z is —N(Ra)—A—B—C…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.