Compositions of nitrates and methods of use thereof

US11096409B2 · kind B2 · utility

Assignee

• HEARTBEET LTD. · GB

Inventors

• Jon Lundberg · Stockholm, SE
• Eddie Weitzberg · Stockholm, SE

Key dates

• Filing date: May 28, 2020
• Grant date: Aug 24, 2021
• Expiry date: May 28, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C01D9/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Described are probiotic compositions for human oral consumption comprising Veillonella bacteria. In some aspects, the probiotic compositions further comprise a salt of nitrate (NO3−) and/or a salt of nitrite (NO2−). In other aspects, the probiotic compositions further comprise a salt of nitrite (NO2−) and a natural source of nitrate. In certain embodiments, the probiotic compositions additionally comprises a polyphenol. Also described herein are methods of enhancing generation of bioactive nitrogen oxides in a human subject, of treating or preventing a gastrointestinal disorder in a human subject, of enhancing athletic performance in a human subject, and of enhancing administration of nitrite or nitrate in a human subject, wherein the human subject is administered the probiotic compositions described herein.