Bacterial membrane nanoparticles as an immunotherapy system for cancer treatment
US11096899B2 · kind B2 · utility
1Cited by
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23Claims
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Key dates
| Filing date | Sep 5, 2019 |
| Grant date | Aug 24, 2021 |
| Priority date | — |
| Expiry date | Sep 5, 2039 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2039/585
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided herein are nanoparticles comprising a polyplex core comprising one or more pH-responsive polymers and one or more anionic immune adjuvants, wherein each pH-responsive polymer comprises ionizable amine groups; and a shell of bacterial cell membrane components at least partially coating the polyplex core, wherein the bacterial cell membrane components comprise TLR 2 and/or TLR 4 agonists. Also provided are methods of stimulating an immune response in a mammal using the nanoparticle.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.