Compositions and methods related to polycytotoxic T cells

US11096965B2 · kind B2 · utility

Assignees

• The Regents of the University of California · US
• ULM UNIVERSITY · DE

Inventors

• Samuel J. Balin · El Segundo, US
• Robert L. Modlin · McNeil, US
• Steffen Stenger · Ulm, DE
• Matteo Pellegrini · West Hollywood, US

Key dates

• Filing date: Apr 4, 2017
• Grant date: Aug 24, 2021
• Expiry date: Aug 31, 2037

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Various aspects of the invention relate to compositions comprising polycytotoxic T cells. Some aspects relate to methods for obtaining a composition comprising polycytotoxic T cells. Some aspects relate to methods of administering a composition comprising polycytotoxic T cells to a subject. Some aspects relate to methods for monitoring an immune response in a subject, comprising determining the concentration of polycytotoxic T cells in the blood of the subject. Some aspects relate to methods for treating a condition or disease in a subject, comprising administering to the subject a composition comprising an antibody, or an antigen-binding portion thereof, that specifically binds to a protein expressed by a polycytotoxic T cell.