UDP glycosyltransferase inhibitors and methods of use

US11098056B2 · kind B2 · utility

Assignee

• Genzyme Corporation · US

Inventors

• Sungtaek Lim · Flemington, US
• Robert H. Barker, Jr. · Easley, US
• Mary A. CROMWELL · Groton, US
• Elina Makino · Winchester, US
• Bradford H. Hirth · Framingham, US
• John Ziqi Jiang · Fryeburg, US
• Sachin Maniar · Beech Grove, US
• Mark Munson · Bound Brook, US
• Yong-Mi Choi · Jeffersonville, US
• Sukanthini Thurairatnam · Bedminster, US
• Kwon Yon Musick · Raritan, US
• James Pribish · Piscataway, US
• Michael R. Angelastro · Mason, US

Key dates

• Filing date: Oct 1, 2019
• Grant date: Aug 24, 2021
• Expiry date: Oct 1, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D519/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Described herein is a compound of Formula (I), and pharmaceutically acceptable salts thereof. Also described herein are compositions and the use of such compositions in methods of treating a variety of diseases and conditions, in particular Krabbe's Disease (KD) and Metachromatic leukodystrophy (MLD).