Patent · US Active

Macrocycle containing aminopyrazole and pyrimidine and pharmaceutical composition and use thereof

US11098060B2 · kind B2 · utility

0Cited by

0References

20Claims

0Family size

Assignees

Inventors

Liguang Dai · Beijing, CN
Xiaowei Duan · Beijing, CN
Yanqing Yang · Beijing, CN
Xijie Liu · Beijing, CN
Hongjuan Li · Beijing, CN
Na Zhao · Beijing, CN
Yinghui Sun · Beijing, CN
Fansheng Kong · Beijing, CN
Jiuqing Zhang · Beijing, CN
Yizhong Zhu · Lianyungang, CN
Ling Yang · Lianyungang, CN
Fei Liu · Nanjing, CN

Key dates

Filing date	Aug 23, 2018
Grant date	Aug 24, 2021
Priority date	—
Expiry date	Aug 23, 2038

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D498/18
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present application relates to a macrocycle containing aminopyrazole and pyrimidine, which is represented by formula (I), a pharmaceutical composition thereof, and a use thereof in inhibiting tropomyosin receptor kinase (Trk) activity and in treating diseases in mammals that are mediated by Trk.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.