Alkenyl and beta-substituted phosphonates as antimicrobial agents

US11098072B2 · kind B2 · utility

Assignees

• THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION · US
• Washington University · US
• George Mason University · US
• St. Louis University · US

Inventors

• Cynthia Dowd · Washington, US
• Xu Wang · 安丰镇, CN
• Robert C. Brothers · Wilmington, US
• Audrey R. Odom JOHN · Chesterfield, US
• Rachel Edwards · Chesterfield, US
• Marvin J. Meyers · Wentzville, US
• Stacy D. ARNETT · Chesterfield, US
• Robin D. COUCH · Fairfax, US
• Kenneth HEIDEL · Washington, US

Key dates

• Filing date: Jun 27, 2018
• Grant date: Aug 24, 2021
• Expiry date: Jun 27, 2038

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present disclosure relates to novel compounds, pharmaceutical compositions, and methods for treating or preventing microbial infection caused by parasites or bacteria, such as Plasmodium falciparum or related Plasmodium parasite species and Mycobacterium tuberculosis or related Mycobacterium bacteria species. The compounds are α,β-unsaturated analogs of fosmidomycin and can inhibit deoxyxylulose phosphate reductoisomerase (Dxr) in many microbes, such as P. falciparum.