Locked nucleic acid cyclic dinucleotide compounds and uses thereof
US11098077B2 · kind B2 · utility
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20Claims
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Key dates
| Filing date | Jul 1, 2017 |
| Grant date | Aug 24, 2021 |
| Priority date | — |
| Expiry date | Feb 17, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N15/113
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides highly active locked nucleic acid cyclic-dinucleotide (LNA-CDN) immune stimulators that activate DCs via the cytoplasmic receptor known as STING (Stimulator of Interferon Genes). In particular, the LNA-CDNs of the present invention are provided in the form of a composition comprising one or more cyclic dinucleotides that induce human STING-dependent type I interferon production, wherein the cyclic dinucleotides present in the composition have at least one 2′, 4′ locked nucleic acids within the cyclic dinucleotide.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.