Patent · US Active

Method and device for separating metabolites or stereoisomers

US11099154B2 · kind B2 · utility

0Cited by

5References

21Claims

0Family size

Assignee

Roche Diagnostics Operations, Inc. · US

Inventors

Uwe Kobold · Wielenbach, DE
Roland Thiele · Murnau am Staffelsee, DE
Noah Weiss · Munich, DE
Lauren Brown · Bingham Farms, US

Key dates

Filing date	Dec 1, 2016
Grant date	Aug 24, 2021
Priority date	—
Expiry date	Dec 1, 2036

Classification

Technology area (CPC H)Electricity
CPC primaryH01J49/0031
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

A method of quantifying the amount of at least two analytes A1 and A2 involving (a) adding at least one salt (S) to at least a portion (P1) of the sample comprising the at least two analytes A1 and A2, (b) ionizing at least a portion of the sample according to (a) thereby forming an analyte flow comprising the analytes A1 and A2 in ionized form, (c) separating the ionized analytes A1 and A2 from each other by using at least one ion mobility separator (124), wherein the analyte flow according to (b) at least partially passes through the ion mobility separator (124), and (d) quantifying the amount of the separated ionized analytes obtained according to (c), wherein A1 is a pharmaceutically active compound C or derivative thereof and A2 is a metabolite or stereoisomer of C.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.