Protein nanocapsules with detachable zwitterionic coating for protein delivery

US11103462B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Yunfeng Lu · Los Angeles, US
• Jie Li · Lo Wu, CN
• Yang Liu · Columbus, US
• Jie Ren · Xiamen, CN
• Jing Wen · Sudbury, US

Key dates

• Filing date: Dec 14, 2016
• Grant date: Aug 31, 2021
• Expiry date: Dec 30, 2036

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to protein nanocapsules that exhibit material properties that change in different in vivo environments. A zwitterion moiety on the surface of the nanocapsule can protect the protein from opsonization in a first environment, yet uncouples from the protein nanocapsule in a second environment (e.g. at a pH of less than 6.5). In embodiments of the invention, the uncoupled protein nanocarrier is then internalized by mammalian cells (e.g. tumor cells).