Methods for treating alzheimer's disease with donepezil transdermal system
US11103463B2 · kind B2 · utility
3Cited by
64References
10Claims
0Family size
Assignee
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Key dates
| Filing date | Apr 23, 2019 |
| Grant date | Aug 31, 2021 |
| Priority date | — |
| Expiry date | May 6, 2039 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/045
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A transdermal delivery system for systemic delivery of donepezil is described, where the system comprises an adhesive matrix drug reservoir layer comprised of a copolymer of acrylic acid/vinyl acetate, triethyl citrate, and donepezil base generated in situ by reaction of donepezil HCl and an alkaline salt. The system is provided for treatment of Alzheimer's disease, and achieves transdermal delivery of the therapeutic agent at steady state that is bioequivalent to administration of the therapeutic agent orally.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.