Multiple oligonucleotide moieties on peptide carrier

US11103587B2 · kind B2 · utility

Assignee

• Genzyme Corporation · US

Inventors

• Timothy Weeden · Waltham, US
• Carol A. Nelson · Westford, US
• Bruce M. Wentworth · Northborough, US
• Nicholas P. CLAYTON · Sudbury, US
• Andrew Leger · Boston, US

Key dates

• Filing date: Feb 1, 2019
• Grant date: Aug 31, 2021
• Expiry date: Feb 1, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2320/32
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure relates to antisense oligonucleotides (AONs), such as phosphorodiamidate morpholino oligonucleotides (PMOs). The present disclosure further relates to the conjugation of multiple PMOs to cationic cell penetrating peptides (CPPs) to enhance the uptake of PMOs into skeletal and cardiac muscle cells.