Bicyclic peptide ligands specific for MT1-MMP
US11103591B2 · kind B2 · utility
8Cited by
1References
24Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 6, 2019 |
| Grant date | Aug 31, 2021 |
| Priority date | — |
| Expiry date | Dec 6, 2039 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of membrane type 1 metalloprotease (MT1-MMP). The invention also describes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups which have utility in imaging and targeted cancer therapy.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.