Metal complexes and fluorination thereof
US11103604B2 · kind B2 · utility
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8Claims
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Key dates
| Filing date | May 2, 2014 |
| Grant date | Aug 31, 2021 |
| Priority date | — |
| Expiry date | Dec 21, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F5/003
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of labelling biological molecules with 18F, via attachment of fluorine to a metal complex, where the metal complex is conjugated to the biological molecule. The invention highlights the incorporation of hydrogen bonding (H-bonding) into the metal complex scaffold, and how this can be utilised to improve the kinetics of fluoride incorporation. Also provided are pharmaceutical compositions, kits and methods of in vivo imaging.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.