Methods for treating neurogenic disorders of the pelvic floor

US11103723B2 · kind B2 · utility

Assignees

• The Board of Trustees of the Leland Stanford Junior University · US
• Circuit Therapeutics, Inc. · US

Inventors

• Karl Deisseroth · Stanford, US
• Elizabeth R. Aden · Berkeley, US
• Viviana Gradinaru · Irvine, US
• Scott L. Delp · Stanford, US

Key dates

• Filing date: Oct 23, 2015
• Grant date: Aug 31, 2021
• Expiry date: Apr 30, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2750/14141
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein are methods for the treatment of bladder dysfunction, including detrusor hyperreflexia and detrusor external sphincter dyssynergia, fecal incontinence, and/or sexual dysfunction in an individual via the use of stably expressed light-responsive opsin proteins capable of selective hyperpolarization or depolarization of the neural cells that innervate the muscles responsible for physiologic functioning of urinary bladder, external urinary sphincter, external anal sphincter, and the male and female genitalia.