Patent · US Active

Process for recovering viral products using functionalised chromatography media

US11103853B2 · kind B2 · utility

0Cited by
1References
13Claims
0Family size

Assignee

Inventor

Key dates

Filing dateJul 14, 2017
Grant dateAug 31, 2021
Priority date
Expiry dateJul 14, 2037

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC12N2799/025
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

The present invention provides a process for recovering a viral product from a composition comprising said product and product-related impurities, which process comprises contacting the composition with a functionalised chromatography medium comprising one or more polymer nanofibres, wherein the viral product comprises a plurality of viruses, virus particles/virions, viral cores, membrane-stripped viruses, viral cores with outer membrane(s) removed and/or capsids removed, or proviruses, each of which contains one or more polynucleotides, and wherein the product-related impurities comprise a plurality of viruses, virus particles/virions, virus-like particles, viral cores, membrane-stripped viruses, viral cores with outer membrane(s) removed and/or capsids removed or proviruses, each of which is substantially devoid of polynucleotides.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.